L-741,742 hydrochloride

Name: L-741,742 hydrochloride
Brand: Tocris Bioscience
SKU: 1004
Price: 184 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 1004

Citations (3)

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Key Product Details

Description:	Highly selective D₄ antagonist
Chemical Name:	5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	417.38

View Full Technical Details for L-741,742 hydrochloride

Biological Activity for L-741,742 hydrochloride

L-741,742 hydrochloride is a potent and highly selective D₄ dopamine receptor antagonist, with K_i values of > 1700, 770 and 3.5 nM at cloned human D₂, D₃ and D₄ receptors.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data for L-741,742 hydrochloride

M. Wt	417.38
Formula	C₂₃H₂₅N₂ClO.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	874882-93-6
PubChem ID	133008
InChi Key	QDMAKDIDFJTXEL-UHFFFAOYSA-N
Smiles	Cl.CC1=C(ON=C1C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-741,742 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.17	10

Preparing Stock Solutions for L-741,742 hydrochloride

The following data is based on the product molecular weight 417.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.96 mL	119.79 mL	239.59 mL
0.5 mM	4.79 mL	23.96 mL	47.92 mL
1 mM	2.40 mL	11.98 mL	23.96 mL
5 mM	0.48 mL	2.40 mL	4.79 mL

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References for L-741,742 hydrochloride

References are publications that support the biological activity of the product.

Rowley 4-Heterocyclylpiperidines as selective high-affinity ligands at the human DA D₄ receptor. J.Med.Chem. 1997 PMID: 9240352
Rowley 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned DA D₄ receptors. J. Med. Chem. 1996 PMID: 8642551

Citations for L-741,742 hydrochloride (3)

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Citations are publications that use Bio-Techne products. Selected citations for L-741,742 hydrochloride include:

Dolma et al. (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 29:829
PMID: 27300435
Root et al. (2015) NE activates DA D4 receptors in the rat lateral habenula. J Neurosci. 35:3460
PMID: 25716845
Bastianetto et al. (2006) Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC Neurosci. 7:28
PMID: 16573831

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