L-741,742 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1004
Highly selective D4 antagonist
Key Product Details
Description
Highly selective D4 antagonist
Product Description
L-741,742 hydrochloride is a potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.Product Specifications
Molecular Weight
417.38
Formula
C23H25N2ClO.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
CAS Number
874882-93-6
PubChem ID
133008
InChI Key
QDMAKDIDFJTXEL-UHFFFAOYSA-N
SMILES
Cl.CC1=C(ON=C1C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=C(Cl)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.17 | 10 |
Preparing Stock Solutions
for L-741,742 hydrochloride
The following data is based on the product molecular weight 417.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.96 mL | 119.79 mL | 239.59 mL |
| 0.5 mM | 4.79 mL | 23.96 mL | 47.92 mL |
| 1 mM | 2.40 mL | 11.98 mL | 23.96 mL |
| 5 mM | 0.48 mL | 2.40 mL | 4.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rowley 4-Heterocyclylpiperidines as selective high-affinity ligands at the human DA D4 receptor. J.Med.Chem. 1997 PMID: 9240352
- Rowley 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned DA D4 receptors. J. Med. Chem. 1996 PMID: 8642551
Product Specific Notices for L-741,742 hydrochloride
For research use only
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