L-741,626

Name: L-741,626
Brand: Tocris Bioscience
SKU: 1003

Catalog # 1003

Citations (10)

COA / SDS

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Key Product Details

Description:	High affinity D₂ antagonist
Chemical Name:	3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
Purity:	≥98% (HPLC)
Molecular Weight:	340.85

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Biological Activity

L-741,626 is a potent D₂ dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D₂, D₃ and D₄ receptors respectively. Centrally active following systemic administration in vivo.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Compound Libraries

L-741,626 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	340.85
Formula	C₂₀H₂₁ClN₂O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	81226-60-0
PubChem ID	133633
InChi Key	LLBLNMUONVVVPG-UHFFFAOYSA-N
Smiles	OC1(CCN(CC2=CNC3=CC=CC=C23)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.09	100
	ethanol	34.09	100

Preparing Stock Solutions

The following data is based on the product molecular weight 340.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.67 mL	29.34 mL
5 mM	0.59 mL	2.93 mL	5.87 mL
10 mM	0.29 mL	1.47 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References

References are publications that support the biological activity of the product.

Millan S33084, a novel, potent, selective, and competitive antagonist at DA D₃-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J.Pharmacol.Exp.Ther. 2000 PMID: 10869411
Pillai Human D2 and D4 DA receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respect Neuropharmacology 1998 PMID: 9833627
Bowery Antagonism of the effects of (+)-PD 128907 on midbrain DA neurones in rat brain slices by a selective D₂ receptor antagonist L-741,626. Br.J.Pharmacol. 1996 PMID: 8968560
Kulagowski 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human DA D₄ receptor. J.Med.Chem. 1996 PMID: 8642550

Citations for L-741,626 (10)

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Citations are publications that use Bio-Techne products. Selected citations for L-741,626 include:

Wang et al. (2019) GPR139 and DA D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact. Front Neurosci. 13:281
PMID: 30971885
Lin et al. (2019) Functional roles of ST8SIA3-mediated sialylation of striatal DA D2 and adenosine A2A receptors. Transl Psychiatry. 9:209
PMID: 31455764
Zhang et al. (2018) Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation. Neuron. 98:918
PMID: 29754751
Xiao et al. (2017) Biased OXTergic Modulation of Midbrain DA Systems. Neuron. 95:368
PMID: 28669546
Newton et al. (2016) Examining the Effects of Sodium Ions on the Binding of Antagonists to DA D 2 and D 3 Receptors PLoS One. 11:e0158808
PMID: 27379794
Wang et al. (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation. J Neurosci. 11:2057
PMID: 26649942
Belinsky et al. (2013) DA receptors in human embryonic stem cell neurodifferentiation. Stem Cells Dev. 22:1522
PMID: 23286225
Billes et al. (2012) Leptin reduces food intake via a DA D2 receptor-dependent mechanism. Mol Metab. 1:86
PMID: 24024122
Dacks et al. (2012) Olfactory modulation by DA in the context of aversive learning. J Neurophysiol. 108:539
PMID: 22552185
Yang et al. (2004) Inhibition of ATP-sensitive potassium channels by halope. Br J Pharmacol. 143:960
PMID: 15533888

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