L-651,582

Tocris Bioscience, part of Bio-Techne | Catalog # 3086

Non-selective Ca2+ channel blocker
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Key Product Details

Description

Non-selective Ca2+ channel blocker

Alternative Names

Carboxyamidotriazole

View all Non-selective Cav Blockers »

Product Description

L-651,582 is an orally active Ca2+ channel blocker; inhibits K+- and carbachol-stimulated Ca2+ influx (IC50 values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activity in vivo and displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro.

Product Specifications

Molecular Weight

424.67

Formula

C17H12Cl3N5O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide

CAS Number

99519-84-3

PubChem ID

108144

InChI Key

WNRZHQBJSXRYJK-UHFFFAOYSA-N

SMILES

ClC1=CC=C(C(C2=C(Cl)C=C(CN3N=NC(C(N)=O)=C3N)C=C2Cl)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.47 100

Preparing Stock Solutions for L-651,582

The following data is based on the product molecular weight 424.67

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.77 mL 23.55 mL
5 mM 0.47 mL 2.35 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.35 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for L-651,582

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-651,582

For research use only

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