L-368,899 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2641
Potent, non-peptide oxytocin receptor antagonist
Key Product Details
Description
Potent, non-peptide oxytocin receptor antagonist
Product Description
L-368,899 hydrochloride is a potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitro and in vivo.Product Specifications
Molecular Weight
627.68
Formula
C26H42N4O5S2.2HCl
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
(2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide dihydrochloride
PubChem ID
90488775
InChI Key
WJPIJZWOCNBGTR-HILSUTFGSA-N
SMILES
CC(C=CC=C1)=C1N2CCN(S(C[C@@]34CC[C@@H](C4(C)C)C[C@@H]3NC([C@@H](N)CCS(C)(=O)=O)=O)(=O)=O)CC2.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 59.12 | 100 | |
| DMSO | 59.12 | 100 |
Preparing Stock Solutions
for L-368,899 hydrochloride
The following data is based on the product molecular weight 627.68
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.59 mL | 7.97 mL | 15.93 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.19 mL |
| 10 mM | 0.16 mL | 0.80 mL | 1.59 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Borthwick Oral oxyt. antagonists. J.Med.Chem. 2010 PMID: 20550119
- Mann Attenuation of PGE2α release in ewes infused with the oxyt. antagonist L-368,899. Domest.Anim.Endocrinol. 2003 PMID: 14550509
- Quattropani Discovery and development of a new class of potent, selective, orally active oxyt. receptor antagonist. J.Med.Chem. 2005 PMID: 16302826
- Williams 1-(((7,7-dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine (L-368,899): an orally bioavailable, non-peptide oxyt. antagonist with potential util J.Med.Chem. 1994 PMID: 8126695
Product Specific Notices for L-368,899 hydrochloride
For research use only
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