KU 55933

Tocris Bioscience, part of Bio-Techne | Catalog # 3544

Potent and selective ATM kinase inhibitor
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Key Product Details

Description

Potent and selective ATM kinase inhibitor

View all ATM and ATR Kinase Inhibitors »

Product Description

KU 55933 is a potent, selective and competitive ATM kinase inhibitor (Ki = 2.2 nM, IC50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro. Acts as a radio- and chemosensitizer for the treatment of cancer.

Product Specifications

Molecular Weight

395.49

Formula

C21H17NO3S2

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one

CAS Number

587871-26-9

PubChem ID

5278396

InChI Key

XRKYMMUGXMWDAO-UHFFFAOYSA-N

SMILES

O=C1C=C(C3=CC=CC4=C3SC5=C(C=CC=C5)S4)OC(N2CCOCC2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.55 100
Ethanol 19.77 50

Preparing Stock Solutions for KU 55933

The following data is based on the product molecular weight 395.49

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for KU 55933

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KU 55933

For research use only

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