KU 0063794
Tocris Bioscience, part of Bio-Techne | Catalog # 3725
Selective mTOR inhibitor
Product Description
KU 0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro.Product Specifications
Molecular Weight
465.54
Formula
C25H31N5O4
Storage
Store at RT
Purity
≥97% (HPLC)
Chemical Name
rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
CAS Number
938440-64-3
PubChem ID
16736978
InChI Key
RFSMUFRPPYDYRD-CALCHBBNSA-N
SMILES
OCC1=C(OC)C=CC(C3=NC2=NC(N5C[C@@H](C)O[C@@H](C)C5)=NC(N4CCOCC4)=C2C=C3)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.66 | 10 |
Preparing Stock Solutions
for KU 0063794
The following data is based on the product molecular weight 465.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.48 mL | 107.40 mL | 214.80 mL |
| 0.5 mM | 4.30 mL | 21.48 mL | 42.96 mL |
| 1 mM | 2.15 mL | 10.74 mL | 21.48 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Garcia-Martinez Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. 2009 PMID: 19402821
Product Specific Notices for KU 0063794
For research use only
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