KT 5823
Tocris Bioscience, part of Bio-Techne | Catalog # 1289
Selective protein kinase G inhibitor
Key Product Details
Description
Selective protein kinase G inhibitor
Product Description
KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.Product Specifications
Molecular Weight
495.53
Formula
C29H25N3O5
Storage
Desiccate at -20°C
Purity
≥95% (HPLC)
Chemical Name
(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolopyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
CAS Number
126643-37-6
PubChem ID
108152
InChI Key
QTYMDECKVKSGSM-YMUMJAELSA-N
SMILES
[H][C@]18O[C@](N6C4=C3N1C2=CC=CC=C2C3=C7C(CN(C7=O)C)=C4C5=CC=CC=C56)([C@]([C@@](OC)=O)(OC)C8)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.78 | 50 |
Preparing Stock Solutions
for KT 5823
The following data is based on the product molecular weight 495.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.04 mL | 20.18 mL | 40.36 mL |
| 2.5 mM | 0.81 mL | 4.04 mL | 8.07 mL |
| 5 mM | 0.40 mL | 2.02 mL | 4.04 mL |
| 25 mM | 0.08 mL | 0.40 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Murthy and Makhlouf Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 1995 PMID: 7840145
- Smolenski Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch.Pharmacol. 1998 PMID: 9721015
- Gadbois Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 1992 PMID: 1528872
Product Specific Notices for KT 5823
For research use only
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