KT 5720
Tocris Bioscience, part of Bio-Techne | Catalog # 1288
Selective protein kinase A inhibitor
Key Product Details
Description
Selective protein kinase A inhibitor
Product Description
KT 5720 is a potent, selective inhibitor of protein kinase A (Ki = 60 nM). Has no effect on PKG or PKC (Ki > 2 μM). Reversibly arrests human skin fibroblasts in the G1 phase.Product Specifications
Molecular Weight
537.61
Formula
C32H31N3O5
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolopyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester
CAS Number
108068-98-0
PubChem ID
9850141
InChI Key
ZHEHVZXPFVXKEY-MWOZDUBJSA-N
SMILES
O[C@@]1(C(OCCCCCC)=O)C[C@@H]2O[C@]1(N3C4=CC=CC=C4C5=C3C6=C(C7=C5CNC7=O)C8=CC=CC=C8N26)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.88 | 50 |
Preparing Stock Solutions
for KT 5720
The following data is based on the product molecular weight 537.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.72 mL | 18.60 mL | 37.20 mL |
| 2.5 mM | 0.74 mL | 3.72 mL | 7.44 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
| 25 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gadbois Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 1992 PMID: 1528872
- Kase K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem.Biophys.Res.Commun. 1987 PMID: 3028414
- Cabell Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons. Int.J.Dev. Neurosci. 1993 PMID: 7689287
Product Specific Notices for KT 5720
For research use only
Loading...
Loading...
Loading...