Key Product Details
Description: | Selective protein kinase A inhibitor |
Chemical Name: | (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester |
Purity: | ≥97% (HPLC) |
Molecular Weight: | 537.61 |
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Citations for KT 5720 (28)
Citations are publications that use Bio-Techne products. Selected citations for KT 5720 include:
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Yuede et al.
(2021)
Pimavanserin, a 5HT 2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease.
J.Neurochem..
156:658
PMID: 33278025 -
Salinar et al.
(2020)
Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs
Antiviral Res.
179
PMID: 32387475 -
Vaden et al.
(2019)
The readily-releasable pool dynamically regulates multivesicular release.
Elife.
8
PMID: 31364987 -
Xu et al.
(2018)
Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β.
EMBO Mol Med.
10
PMID: 30093491 -
Patra et al.
(2018)
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Nat Cell Biol.
20:811
PMID: 29941929 -
Cruz et al.
(2018)
Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy.
J Biol Chem.
293:11837
PMID: 29899111 -
Cornelison et al.
(2016)
Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons
Neuroscience.
339:491
PMID: 27746346 -
Cui et al.
(2016)
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Elife.
5:e13185
PMID: 26920222 -
Li et al.
(2016)
Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.
J Clin Invest.
126:389
PMID: 26657863 -
Weng et al.
(2016)
Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms.
Front Cell Neurosci.
10:247
PMID: 27826228 -
Parnell et al.
(2015)
Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
Invest Ophthalmol Vis Sci.
1853:1749
PMID: 25913012 -
Thakran et al.
(2015)
Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions.
PLoS One.
56:177
PMID: 25525174 -
Smith et al.
(2015)
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
PLoS One.
10:e0136546
PMID: 26414859 -
Brignell et al.
(2015)
Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B.
J Neurosci.
10:e0121285
PMID: 25793374 -
Merino et al.
(2015)
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
Br J Pharmacol.
10:e0132884
PMID: 26222156 -
Chang et al.
(2015)
Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin.
Sci Rep.
5:10256
PMID: 26194093 -
Liu and Zhuo
(2014)
Loss of long-term depression in the insular cortex after tail amputation in adult mice.
Mol Pain.
10:1
PMID: 24398034 -
Campos et al.
(2014)
Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist.
J Neurosci.
34:12636
PMID: 25232103 -
Guo and Feng
(2012)
OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
Exp Cell Res.
318:2004
PMID: 22652455 -
Nakao et al.
(2012)
The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa.
PLoS One.
7:e32472
PMID: 22485131 -
Lee et al.
(2012)
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Nature.
492:123
PMID: 23143333 -
Hook et al.
(2012)
DArgic modulation of ganglion-cell photoreceptors in rat.
Biochim Biophys Acta.
35:507
PMID: 22304466 -
Meitzen et al.
(2011)
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
J Neurochem.
116:984
PMID: 21143600 -
Sowa et al.
(2010)
Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate.
J Neurosci.
30:10282
PMID: 20685973 -
Dai et al.
(2008)
A crucial role for cAMP and protein kinase A in D1 DA receptor regulated intracellular calcium transients.
Neurosignals.
16:112
PMID: 18253052 -
Kravtsov et al.
(2007)
Altered Ca(2+) handling by ryanodine receptor and Na(+)-Ca(2+) exchange in the heart from ovariectomized rats: role of protein kinase A.
Am J Physiol Cell Physiol.
292:C1625
PMID: 17166940 -
O'Riordan et al.
(2006)
Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors.
PLoS One.
26:4870
PMID: 16672661 -
Agopyan et al.
(2004)
TRPV1 receptors mediate particulate matter-induced apoptosis.
Am J Physiol Lung Cell Mol Physiol.
286:L563
PMID: 14633515
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