KT 5720

Name: KT 5720
Brand: Tocris Bioscience
SKU: 1288
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1288

Citations (28)

(1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Selective protein kinase A inhibitor
Chemical Name:	(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester
Purity:	≥97% (HPLC)
Molecular Weight:	537.61

View Full Technical Details for KT 5720

Biological Activity for KT 5720

KT 5720 is a potent, selective inhibitor of protein kinase A (K_i = 60 nM). Has no effect on PKG or PKC (K_i > 2 μM). Reversibly arrests human skin fibroblasts in the G₁ phase.

Technical Data for KT 5720

M. Wt	537.61
Formula	C₃₂H₃₁N₃O₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	108068-98-0
PubChem ID	9850141
InChi Key	ZHEHVZXPFVXKEY-MWOZDUBJSA-N
Smiles	O[C@@]1(C(OCCCCCC)=O)C[C@@H]2O[C@]1(N3C4=CC=CC=C4C5=C3C6=C(C7=C5CNC7=O)C8=CC=CC=C8N26)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KT 5720

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.88	50

Preparing Stock Solutions for KT 5720

The following data is based on the product molecular weight 537.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.72 mL	18.60 mL	37.20 mL
2.5 mM	0.74 mL	3.72 mL	7.44 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
25 mM	0.07 mL	0.37 mL	0.74 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for KT 5720

References are publications that support the biological activity of the product.

Cabell Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons. Int.J.Dev. Neurosci. 1993 PMID: 7689287
Gadbois Multiple kinase arrest points in the G₁ phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 1992 PMID: 1528872
Kase K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem.Biophys.Res.Commun. 1987 PMID: 3028414

Citations for KT 5720 (28)

Showing 1 - 10 of 28 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for KT 5720 include:

Yuede et al. (2021) Pimavanserin, a 5HT _2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease. J.Neurochem.. 156:658
PMID: 33278025
Salinar et al. (2020) Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs Antiviral Res. 179
PMID: 32387475
Vaden et al. (2019) The readily-releasable pool dynamically regulates multivesicular release. Elife. 8
PMID: 31364987
Xu et al. (2018) Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β. EMBO Mol Med. 10
PMID: 30093491
Patra et al. (2018) Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol. 20:811
PMID: 29941929
Cruz et al. (2018) Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy. J Biol Chem. 293:11837
PMID: 29899111
Cornelison et al. (2016) Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons Neuroscience. 339:491
PMID: 27746346
Cui et al. (2016) Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. Elife. 5:e13185
PMID: 26920222
Li et al. (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest. 126:389
PMID: 26657863
Weng et al. (2016) Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms. Front Cell Neurosci. 10:247
PMID: 27826228
Parnell et al. (2015) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Invest Ophthalmol Vis Sci. 1853:1749
PMID: 25913012
Thakran et al. (2015) Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. PLoS One. 56:177
PMID: 25525174
Smith et al. (2015) The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. PLoS One. 10:e0136546
PMID: 26414859
Brignell et al. (2015) Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B. J Neurosci. 10:e0121285
PMID: 25793374
Merino et al. (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote. Br J Pharmacol. 10:e0132884
PMID: 26222156
Chang et al. (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep. 5:10256
PMID: 26194093
Liu and Zhuo (2014) Loss of long-term depression in the insular cortex after tail amputation in adult mice. Mol Pain. 10:1
PMID: 24398034
Campos et al. (2014) Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist. J Neurosci. 34:12636
PMID: 25232103
Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res. 318:2004
PMID: 22652455
Nakao et al. (2012) The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS One. 7:e32472
PMID: 22485131
Lee et al. (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca²⁺ and cAMP. Nature. 492:123
PMID: 23143333
Hook et al. (2012) DArgic modulation of ganglion-cell photoreceptors in rat. Biochim Biophys Acta. 35:507
PMID: 22304466
Meitzen et al. (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 116:984
PMID: 21143600
Sowa et al. (2010) Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate. J Neurosci. 30:10282
PMID: 20685973
Dai et al. (2008) A crucial role for cAMP and protein kinase A in D1 DA receptor regulated intracellular calcium transients. Neurosignals. 16:112
PMID: 18253052
Kravtsov et al. (2007) Altered Ca(2+) handling by ryanodine receptor and Na(+)-Ca(2+) exchange in the heart from ovariectomized rats: role of protein kinase A. Am J Physiol Cell Physiol. 292:C1625
PMID: 17166940
O'Riordan et al. (2006) Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors. PLoS One. 26:4870
PMID: 16672661
Agopyan et al. (2004) TRPV1 receptors mediate particulate matter-induced apoptosis. Am J Physiol Lung Cell Mol Physiol. 286:L563
PMID: 14633515

There are no citations that match your criteria.

Showing 1 - 10 of 28 citations Showing All

Customer Reviews for KT 5720 (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Showing 1 - 1 of 1 review Showing All

Filter By:

Excellent PKA inhibitor

Name: Gaurang Trivedi

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: Stem Cells

It is an excellent inhibitor for PKA.

PMID: 31554738 Reference

There are no reviews that match your criteria.

Showing 1 - 1 of 1 review Showing All

Product Documents for KT 5720

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.