KT 182
Tocris Bioscience, part of Bio-Techne | Catalog # 6738
Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Key Product Details
Description
Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Product Description
KT 182 is a potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 1.7 nM). KT 182 exhibits selectively for ABHD6 over other brain and liver serine hydrolases, but does exhibit some activity at carboxylesterase-1. KT 182 inhibits ABHD6 activity in the brain and liver in mice following intraperitoneal administration.Product Specifications
Molecular Weight
438.53
Formula
C27H26N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
[4-[3'-(Hydroxymethyl)[1,1'-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone
CAS Number
1402612-62-7
PubChem ID
53364491
InChI Key
GICNKPZHUCVFNM-UHFFFAOYSA-N
SMILES
OCC1=CC=CC(C2=CC=C(C3=CN(C(N4CCCCC4C5=CC=CC=C5)=O)N=N3)C=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.85 | 100 |
Preparing Stock Solutions
for KT 182
The following data is based on the product molecular weight 438.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.40 mL | 22.80 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for KT 182
For research use only
Loading...
Loading...