KL 465

Name: KL 465
Brand: Tocris Bioscience
SKU: 8854

Tocris Bioscience, part of Bio-Techne | Catalog # 8854

COA / SDS

MAGE-A3 Degrader (PROTAC®)

Key Product Details

Description:	MAGE-A3 Degrader (PROTAC^®)
Chemical Name:	(2S,4R)-N-(2-(2-(2-(2-((4-(Furan-2-carbonyl)piperazin-1-yl)methyl)-4-(1H-indazol-4-yl)phenoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1021.2

View Full Technical Details for KL 465

Technical Data
Citations

Biological Activity for KL 465

KL 465 is a MAGE-A3 Degrader (PROTAC^®) (DC₅₀ = 2 μM; D_max = 60%). MAGE-A3 degradation with KL 465 decreases cancer cell viability and is VHL dependent.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for KL 465

M. Wt	1021.2
Formula	C₅₆H₆₀N₈O₉S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3057446-82-6
InChi Key	MQOTXOOWIOCPNH-IYCLWVRSSA-N
Smiles	O=C(C1=CC=CO1)N2CCN(CC2)CC3=CC(C4=CC=CC5=C4C=NN5)=CC=C3OCCOCCOC6=CC(C7=C(N=CS7)C)=CC=C6CNC([C@@H]8C[C@H](CN8C([C@H](C(C)C)N9CC%10=C(C9=O)C=CC=C%10)=O)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KL 465

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	51.06	50

Preparing Stock Solutions for KL 465

The following data is based on the product molecular weight 1021.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.96 mL	9.79 mL	19.58 mL
2.5 mM	0.39 mL	1.96 mL	3.92 mL
5 mM	0.20 mL	0.98 mL	1.96 mL
25 mM	0.04 mL	0.20 mL	0.39 mL

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References for KL 465

References are publications that support the biological activity of the product.

Li Development of ligands and degraders targeting MAGE-A3. J.Am.Chem.Soc. 2024 PMID: 39190582