KJ Pyr 9
Tocris Bioscience, part of Bio-Techne | Catalog # 5306
High affinity Myc inhibitor
Product Description
KJ Pyr 9 is a high affinity Myc inhibitor (Kd = 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant.Product Specifications
Molecular Weight
385.37
Formula
C22H15N3O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide
CAS Number
581073-80-5
PubChem ID
85855478
InChI Key
GTTDVYCKFQYVNN-UHFFFAOYSA-N
SMILES
O=C(N)C(C=C1)=CC=C1C2=CC(C3=CC=CO3)=NC(C4=CC=C([N+]([O-])=O)C=C4)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.54 | 100 |
Preparing Stock Solutions
for KJ Pyr 9
The following data is based on the product molecular weight 385.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.97 mL | 25.95 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.19 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hart Inhibitor of MYC identified in a Kröhnke pyridine library. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 25114221
Product Specific Notices for KJ Pyr 9
For research use only
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