Kifunensine

Name: Kifunensine
Brand: Tocris Bioscience
SKU: 3207
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3207

(1)

Citations (31)

COA / SDS

Inhibitor of class I α-mannosidases

Key Product Details

Description:	Inhibitor of class I α-mannosidases
Chemical Name:	(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
Molecular Weight:	232.19

View Full Technical Details for Kifunensine

Technical Data
Citations / Reviews (1)

Biological Activity for Kifunensine

Kifunensine is an inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Kifunensine inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with K_i values of 130 and 23 nM respectively. Kifunensine disrupts normal trafficking of the GLUT1 transporter, leading to decreased glucose uptake in human renal epithelial cells. Kifunensine impaires tumour cell aggregation in human ovarian cancer cells in vitro.

Technical Data for Kifunensine

M. Wt	232.19
Formula	C₈H₁₂N₂O₆
Storage	Store at -20°C
CAS Number	109944-15-2
PubChem ID	130611
InChi Key	OIURYJWYVIAOCW-PQMKYFCFSA-N
Smiles	O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)N2[C@@]([H])1NC(C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Kifunensine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.16	5 with sonication

Preparing Stock Solutions for Kifunensine

The following data is based on the product molecular weight 232.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	86.14 mL	430.68 mL	861.36 mL
0.25 mM	17.23 mL	86.14 mL	172.27 mL
0.5 mM	8.61 mL	43.07 mL	86.14 mL
2.5 mM	1.72 mL	8.61 mL	17.23 mL

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References for Kifunensine

References are publications that support the biological activity of the product.

Hamester Prognostic relevance of the Golgi mannosidase MAN1A1 in ovarian cancer: impact of N-glycosylation on tumour cell aggregation. Br.J.Cancer 2019 PMID: 31659304
Elbein Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem.
Xiong Pharmacologic inhibition of N-linked glycan trimming with kifunensine disrupts GLUT1 trafficking and glucose uptake. Int.J.Mol.Sci. 2018 PMID: 29562594
Hering A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 2005 PMID: 16292820