Ki 8751

Tocris Bioscience, part of Bio-Techne | Catalog # 2542

COA / SDS

Potent, selective VEGFR-2 inhibitor

Key Product Details

Description:	Potent, selective VEGFR-2 inhibitor
Chemical Name:	N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
Purity:	≥97% (HPLC)
Molecular Weight:	469.41

View Full Technical Details for Ki 8751

Technical Data
Citations

Biological Activity for Ki 8751

Ki 8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC₅₀ = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC₅₀ values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC₅₀ > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo; antiangiogenic.

Compound Libraries for Ki 8751

Ki 8751 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Ki 8751

M. Wt	469.41
Formula	C₂₄H₁₈F₃N₃O₄
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	228559-41-9
PubChem ID	11317348
InChi Key	LFKQSJNCVRGFCC-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=C2C(OC3=CC=C(NC(=O)NC4=CC=C(F)C=C4F)C(F)=C3)=CC=NC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ki 8751

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.94	100

Preparing Stock Solutions for Ki 8751

The following data is based on the product molecular weight 469.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.65 mL	21.30 mL
5 mM	0.43 mL	2.13 mL	4.26 mL
10 mM	0.21 mL	1.07 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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Reconstitution Calculator

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References for Ki 8751

References are publications that support the biological activity of the product.

Kubo Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumour activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas. J.Med.Chem. 2005 PMID: 15743179