KH 7

Name: KH 7
Brand: Tocris Bioscience
SKU: 3834
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3834

(1)

Citations (21)

COA / SDS

Selective soluble adenylyl cyclase inhibitor

Key Product Details

Description:	Selective soluble adenylyl cyclase inhibitor
Chemical Name:	(±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
Purity:	≥99% (HPLC)
Molecular Weight:	419.3

View Full Technical Details for KH 7

Technical Data
Citations / Reviews (1)

Biological Activity for KH 7

KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC₅₀ = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.

Technical Data for KH 7

M. Wt	419.3
Formula	C₁₇H₁₅BrN₄O₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	330676-02-3
PubChem ID	6843191
InChi Key	GEHVZUUHMWNMAY-UHFFFAOYSA-N
Smiles	OC(C=CC(Br)=C2)=C2/C=N/NC(C(C)SC1=NC(C=CC=C3)=C3N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KH 7

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.93	100

Preparing Stock Solutions for KH 7

The following data is based on the product molecular weight 419.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.85 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for KH 7

References are publications that support the biological activity of the product.

Stessin Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J.Biol.Chem. 2006 PMID: 16627466
Hess The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Develop.Cell
Kumar Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J.Biol.Chem. 2009 PMID: 19336406