Ketoconazole

Tocris Bioscience, part of Bio-Techne | Catalog # 1103

Cytochrome P450c17 inhibitor
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Key Product Details

Description

Cytochrome P450c17 inhibitor

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Product Description

Ketoconazole is an inhibitor of cytochrome P450c17. Enhances the formation of myelin basic protein-positive oligodendrocytes from oligodendrocyte progenitor cells in vitro and promotes remyelination in vivo. Also an antifungal agent. Brain penetrant.

Product Specifications

Molecular Weight

531.44

Formula

C26H28Cl2N4O4

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine

CAS Number

65277-42-1

PubChem ID

456201

InChI Key

XMAYWYJOQHXEEK-OZXSUGGESA-N

SMILES

ClC1=CC(Cl)=[C@]([C@]3(OC[C@@](COC4=CC=C(N5CCN(C(C)=O)CC5)C=C4)([H])O3)CN2C=CN=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.86 75
Ethanol 26.57 50

Preparing Stock Solutions for Ketoconazole

The following data is based on the product molecular weight 531.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.51 mL 12.54 mL 25.09 mL
3.75 mM 0.50 mL 2.51 mL 5.02 mL
7.5 mM 0.25 mL 1.25 mL 2.51 mL
37.5 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ketoconazole

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ketoconazole

For research use only

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