Ketoconazole

Name: Ketoconazole
Brand: Tocris Bioscience
SKU: 1103
Price: 147 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 1103

Citations (4)

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Key Product Details

Description:	Cytochrome P450c17 inhibitor
Chemical Name:	cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine
Purity:	≥99% (HPLC)
Molecular Weight:	531.44

View Full Technical Details for Ketoconazole

Biological Activity for Ketoconazole

Ketoconazole is an inhibitor of cytochrome P450c17. Enhances the formation of myelin basic protein-positive oligodendrocytes from oligodendrocyte progenitor cells in vitro and promotes remyelination in vivo. Also an antifungal agent. Brain penetrant.

Technical Data for Ketoconazole

M. Wt	531.44
Formula	C₂₆H₂₈Cl₂N₄O₄
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	65277-42-1
PubChem ID	456201
InChi Key	XMAYWYJOQHXEEK-OZXSUGGESA-N
Smiles	ClC1=CC(Cl)=[C@]([C@]3(OC[C@@](COC4=CC=C(N5CCN(C(C)=O)CC5)C=C4)([H])O3)CN2C=CN=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ketoconazole

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	26.57	50
	DMSO	39.86	75

Preparing Stock Solutions for Ketoconazole

The following data is based on the product molecular weight 531.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	2.51 mL	12.54 mL	25.09 mL
3.75 mM	0.50 mL	2.51 mL	5.02 mL
7.5 mM	0.25 mL	1.25 mL	2.51 mL
37.5 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for Ketoconazole

References are publications that support the biological activity of the product.

Hubler Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 2018 PMID: 30046109
Madhavan Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. 2018 PMID: 30046099
Dumaine Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 1998 PMID: 9694927
Kuhn-Velten Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 1992 PMID: 1472102
Ayub and Levell Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 1989 PMID: 2724954

Citations for Ketoconazole (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Ketoconazole include:

Lu et al. (2019) Inhibition of proliferation and migration of melanoma cells by ketoconazole and Ganoderma immunomodulatory proteins. Oncol Lett. 18:891
PMID: 31289567
Green et al. (2016) Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury. Mol Pain. 12
PMID: 27411353
Green et al. (2013) Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury. Pain. 154:2512
PMID: 23891895
Ruparel et al. (2012) The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. Mol Pain. 8:73
PMID: 23006841

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