Ketanserin tartrate
Tocris Bioscience, part of Bio-Techne | Catalog # 0908
Selective 5-HT2A antagonist. Also antagonist at 5-HT1D
Key Product Details
Description
Selective 5-HT2A antagonist. Also antagonist at 5-HT1D
Alternative Names
R 41 468
Product Description
Ketanserin tartrate is a selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.Product Specifications
Molecular Weight
545.52
Formula
C22H22FN3O3.C4H6O6
Storage
Store at RT
Purity
≥97% (HPLC)
Chemical Name
3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione (L)-tartrate
CAS Number
83846-83-7
PubChem ID
135348
InChI Key
KMTLTEVOQLMYRS-UHFFFAOYSA-N
SMILES
OC(C(O)C(O)=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=O)NC3=CC=CC=C3C2=O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.45 | 10 |
Preparing Stock Solutions
for Ketanserin tartrate
The following data is based on the product molecular weight 545.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.33 mL | 91.66 mL | 183.31 mL |
| 0.5 mM | 3.67 mL | 18.33 mL | 36.66 mL |
| 1 mM | 1.83 mL | 9.17 mL | 18.33 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zgombick Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes. Eur.J.Pharmacol. 1995 PMID: 8549648
- Razzaque Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein. Eur.J.Pharmacol. 1995 PMID: 7498311
- Van Nueten Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors. J.Pharmacol.Exp.Ther. 1981 PMID: 6113280
- Leyson Receptor binding profile of R41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 1981 PMID: 6261070
Product Specific Notices for Ketanserin tartrate
For research use only
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