Ketanserin tartrate

Name: Ketanserin tartrate
Brand: Tocris Bioscience
SKU: 0908
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0908

(2)

Citations (64)

COA / SDS

Selective 5-HT2A antagonist. Also antagonist at 5-HT1D

Key Product Details

Description:	Selective 5-HT_2A antagonist. Also antagonist at 5-HT_1D
Alternative Names:	R 41 468
Chemical Name:	3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate
Purity:	≥97% (HPLC)
Molecular Weight:	545.52

View Full Technical Details for Ketanserin tartrate

Technical Data
Citations / Reviews (2)

Biological Activity for Ketanserin tartrate

Ketanserin tartrate is a selective 5-HT_2A serotonin receptor antagonist; can also be used to discriminate between 5-HT_1D and 5-HT_1B receptor subtypes.

Technical Data for Ketanserin tartrate

M. Wt	545.52
Formula	C₂₂H₂₂FN₃O₃.C₄H₆O₆
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	83846-83-7
PubChem ID	135348
InChi Key	KMTLTEVOQLMYRS-UHFFFAOYSA-N
Smiles	OC(C(O)C(O)=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=O)NC3=CC=CC=C3C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ketanserin tartrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	5.45	10

Preparing Stock Solutions for Ketanserin tartrate

The following data is based on the product molecular weight 545.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.33 mL	91.66 mL	183.31 mL
0.5 mM	3.67 mL	18.33 mL	36.66 mL
1 mM	1.83 mL	9.17 mL	18.33 mL
5 mM	0.37 mL	1.83 mL	3.67 mL

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Reconstitution Calculator

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References for Ketanserin tartrate

References are publications that support the biological activity of the product.

Zgombick Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes. Eur.J.Pharmacol. 1995 PMID: 8549648
Razzaque Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein. Eur.J.Pharmacol. 1995 PMID: 7498311
Van Nueten Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT₂ serotonergic receptors. J.Pharmacol.Exp.Ther. 1981 PMID: 6113280
Leyson Receptor binding profile of R41 468, a novel antagonist at 5-HT₂ receptors. Life Sci. 1981 PMID: 6261070