KC7F2
Tocris Bioscience, part of Bio-Techne | Catalog # 4324
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
Key Product Details
Description
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
Product Description
KC7F2 is an inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.Product Specifications
Molecular Weight
570.38
Formula
C16H16Cl4N2O4S4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
CAS Number
927822-86-4
PubChem ID
16047442
InChI Key
REQLACDIZMLXIC-UHFFFAOYSA-N
SMILES
ClC1=CC=C(Cl)C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.04 | 100 |
Preparing Stock Solutions
for KC7F2
The following data is based on the product molecular weight 570.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.75 mL | 8.77 mL | 17.53 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.51 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.75 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Koh Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 2009 PMID: 19789327
- Narita Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 2009 PMID: 19789328
Product Specific Notices for KC7F2
For research use only
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