KC7F2

Name: KC7F2
Brand: Tocris Bioscience
SKU: 4324
Price: 110 USD

Catalog # 4324 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

Key Product Details

Description:	HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
Chemical Name:	N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	570.38

View Full Technical Details for KC7F2

Biological Activity for KC7F2

KC7F2 is an inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.

Technical Data for KC7F2

M. Wt	570.38
Formula	C₁₆H₁₆Cl₄N₂O₄S₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	927822-86-4
PubChem ID	16047442
InChi Key	REQLACDIZMLXIC-UHFFFAOYSA-N
Smiles	ClC1=CC=C(Cl)C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KC7F2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	57.04	100

Preparing Stock Solutions for KC7F2

The following data is based on the product molecular weight 570.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.75 mL	8.77 mL	17.53 mL
5 mM	0.35 mL	1.75 mL	3.51 mL
10 mM	0.18 mL	0.88 mL	1.75 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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References for KC7F2

References are publications that support the biological activity of the product.

Narita Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 2009 PMID: 19789328
Koh Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 2009 PMID: 19789327

Citations for KC7F2 (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for KC7F2 include:

Hannes M et al. (2020) LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes. Front Immunol. 11:353
PMID: 32210962
Dean H et al. (2020) Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. Sci Rep. 10:8388
PMID: 32433492

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