K 03861
Tocris Bioscience, part of Bio-Techne | Catalog # 6789
Potent CDK2 inhibitor
Key Product Details
Description
Potent CDK2 inhibitor
Alternative Names
AUZ 454
Product Description
K 03861 is a potent Cdk2 inhibitor (Kd values are 9.7, 15.4, 18.6 and 50 nM at Cdk2 (C118L/A144C), Cdk2 (A144C), Cdk2 (C118L), and Cdk (WT) respectively. Competes with cyclin binding to inhibit Cdk2 kinase activity in vitro.Product Specifications
Molecular Weight
501.51
Formula
C24H26F3N7O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea
CAS Number
853299-07-7
InChI Key
PWDLXPJQFNVTNL-UHFFFAOYSA-N
SMILES
CN1CCN(CC2=C(C=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2)C(F)(F)F)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.08 | 50 | |
| Ethanol | 50.15 | 100 |
Preparing Stock Solutions
for K 03861
The following data is based on the product molecular weight 501.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.97 mL | 19.94 mL |
| 5 mM | 0.40 mL | 1.99 mL | 3.99 mL |
| 10 mM | 0.20 mL | 1.00 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Alexander Type II inhibitors targeting Cdk2 ACS.Chem.Biol 2015 PMID: 26158339
- Song NEUROG1 regulates CDK2 to promote proliferation in otic progenitors Stem Cell Reports 2017 PMID: 29033307
Product Specific Notices for K 03861
For research use only
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