JTE 907

Tocris Bioscience, part of Bio-Techne | Catalog # 2479

(1)

Citations (46)

COA / SDS

Selective CB2 receptor inverse agonist

Key Product Details

Description:	Selective CB₂ receptor inverse agonist
Chemical Name:	N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	438.48

View Full Technical Details for JTE 907

Technical Data
Citations / Reviews (1)

Biological Activity for JTE 907

JTE 907 is a highly selective cannabinoid CB₂ receptor inverse agonist. Binds with high affinity to rat, mouse and human CB₂ receptors (K_i values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo.

Technical Data for JTE 907

M. Wt	438.48
Formula	C₂₄H₂₆N₂O₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	282089-49-0
PubChem ID	9867770
InChi Key	GRAJFFFXJYFVOC-UHFFFAOYSA-N
Smiles	CCCCCOC1=C2NC(=O)C(=CC2=CC=C1OC)C(=O)NCC1=CC2=C(OCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JTE 907

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.85	100
	ethanol	4.38	10

Preparing Stock Solutions for JTE 907

The following data is based on the product molecular weight 438.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.40 mL	22.81 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for JTE 907

References are publications that support the biological activity of the product.

Ueda Involvement of cannabinoid CB₂ receptor-mediated response and efficacy of cannabinoid CB₂ receptor inverse agonist, JTE 907, in cutaneous inflammation in mice. Eur.J.Pharmacol. 2005 PMID: 16153638
Maekawa The cannabinoid CB₂ receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur.J.Pharmacol. 2006 PMID: 16824511
Iwamura In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB₂ receptor. J.Pharmacol.Exp.Ther. 2001 PMID: 11160626