JP-2-196 alkyne

Product Description

JP-2-196 alkyne is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM1. By facilitating E3 ligase recruitment, JP-2-196 alkyne induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders. JP-2-196 alkyne is an alkyne functionalized version of JP-2-196 (Cat. No. 8046).

Solubility

Preparing Stock Solutions for JP-2-196 alkyne

The following data is based on the product molecular weight 312.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.01 mL	32.01 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Toriki Rational chemical design of molecular glue Degraders. ACS Cent.Sci. 2023 PMID: 37252349