JNJ 78911118

Name: JNJ 78911118
Brand: Tocris Bioscience
SKU: 8970

Tocris Bioscience, part of Bio-Techne | Catalog # 8970

COA / SDS

Selective GluN2A antagonist, blood-brain barrier penetrant

Key Product Details

Description:	Selective GluN2A antagonist, blood-brain barrier penetrant
Chemical Name:	5-(2-(4-Chloropyridin-2-yl)-2,2-difluoroethoxy)-6-methyl-N-(pyridin-3-ylmethyl)pyrazine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	419.82

View Full Technical Details for JNJ 78911118

Technical Data
Citations

Biological Activity for JNJ 78911118

JNJ 78911118 is a potent, GluN2A-selective NMDA antagonist (IC₅₀ = 44 nM). JNJ 78911118 shows >200-fold selectivity against GluN1/2B, 2C and 2D receptors. In vitro, JNJ 78911118 promotes increases in dendritic complexity and synapse number. In vivo, JNJ 78911118 increases mEPSC frequency in rat cortical neurons, and heart rate and blood pressure in rat toxicological studies. JNJ 78911118 is orally bioavailable and blood-brain barrier penetrant.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the JNJ 78911118 probe summary on the SGC website.

Technical Data for JNJ 78911118

M. Wt	419.82
Formula	C₁₉H₁₆ClF₂N₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	YPXUKPNZQTWCRR-UHFFFAOYSA-N
Smiles	CC1=C(N=CC(C(NCC2=CN=CC=C2)=O)=N1)OCC(F)(C3=NC=CC(Cl)=C3)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 78911118

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.98	100
	ethanol	41.98	100

Preparing Stock Solutions for JNJ 78911118

The following data is based on the product molecular weight 419.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.91 mL	23.82 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for JNJ 78911118

References are publications that support the biological activity of the product.

Lord Pharmacological characterisation of JNJ-78911118, a novel, centrally-penetrant, selective GluN2A antagonist. Br.J.Pharmacol. 2025 PMID: 40361296
Bischoff Design, synthesis, and characterization of GluN2A negative allosteric modulators suitable for in vivo exploration. J.Med.Chem. 2025 PMID: 39960408