Tocris Bioscience a Bio-Techne Brand
Key Product Details
|Description:||Potent and selective P2X7 antagonist; brain penetrant|
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Citations for JNJ 47965567 (2)
Citations are publications that use Bio-Techne products. Selected citations for JNJ 47965567 include:
McEwan et al.
Autocrine regulation of wound healing by ATP release and P2Y 2 receptor activation
Uderhardt et al.
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
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Customer Reviews for JNJ 47965567 (3)
Species: MouseAssay Type: In VivoCell Line/Tissue: phagocyteDMSO dilution 100 μM
Species: MouseAssay Type: In VivoCell Line/Tissue: Hippocampal neuronsI have used this product emulsified in 30% sulphoxymethylester, and injected them sub-cutaneously to study IL-1beta release mechanism in the hippocampus of the brain. I am currently working on its effect on hippocampal neurons in culture.Followed publication by Bhattacharya et al, Br J Pharmacol. 2013 Oct;170(3):624-40. doi: 10.1111/bph.12314 for in vivo and in vitro usage.
Species: MouseAssay Type: Ex VivoUsed to block a potentially P2X7-dependent process, but no effect was observed. No positive control so unsure if the drug actually blocked its target. More experiments needed.
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