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JNJ 47965567

Tocris Bioscience a Bio-Techne Brand

JNJ 47965567 | CAS No. 1428327-31-4 | Potent and selective P2X7 antagonist; brain penetrant
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Key Product Details

Description: Potent and selective P2X7 antagonist; brain penetrant
Chemical Name: 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide
Purity: ≥98% (HPLC)
Molecular Weight: 488.64

Citations for JNJ 47965567 (2)

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Customer Reviews for JNJ 47965567 (3)

4.3 out of 5
3 customer ratings
5 stars
67%
4 stars
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3 stars
33%
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1 star
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  • Good inhibitor
    Name: Stefan Uderhardt
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: phagocyte
    DMSO dilution 100 μM
    JNJ 47965567 Serum 5299
  • In vivo usage
    Name: Spandita Dutta
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: Hippocampal neurons
    I have used this product emulsified in 30% sulphoxymethylester, and injected them sub-cutaneously to study IL-1beta release mechanism in the hippocampus of the brain. I am currently working on its effect on hippocampal neurons in culture.
    Followed publication by Bhattacharya et al, Br J Pharmacol. 2013 Oct;170(3):624-40. doi: 10.1111/bph.12314 for in vivo and in vitro usage.
    JNJ 47965567 Serum 5299
  • P2X7 blocker
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Used to block a potentially P2X7-dependent process, but no effect was observed. No positive control so unsure if the drug actually blocked its target. More experiments needed.

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Product Documents for JNJ 47965567

Certificate of Analysis

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