JNJ 47965567

Name: JNJ 47965567
Brand: Tocris Bioscience
SKU: 5299
Rating: 4 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5299

(3)

Citations (33)

COA / SDS

Potent and selective P2X7 antagonist; brain penetrant

Key Product Details

Description:	Potent and selective P2X₇ antagonist; brain penetrant
Chemical Name:	2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	488.64

View Full Technical Details for JNJ 47965567

Technical Data
Citations / Reviews (3)

Biological Activity for JNJ 47965567

JNJ 47965567 is a potent and selective P2X₇ antagonist (pIC₅₀ values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP-induced IL-1β release from monocytes in vitro and from rat brain in vivo. Attenuates amphetamine-induced hyperactivity in rats. Brain penetrant.

Compound Libraries for JNJ 47965567

JNJ 47965567 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 47965567

M. Wt	488.64
Formula	C₂₈H₃₂N₄O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1428327-31-4
PubChem ID	66553218
InChi Key	XREFXUCWSYMIOG-UHFFFAOYSA-N
Smiles	O=C(NCC4(CCOCC4)N3CCN(C5=CC=CC=C5)CC3)C1=CC=CN=C1SC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 47965567

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	24.43	50
	DMSO	48.86	100

Preparing Stock Solutions for JNJ 47965567

The following data is based on the product molecular weight 488.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.23 mL	20.46 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.20 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for JNJ 47965567

References are publications that support the biological activity of the product.

Letavic Synthesis and pharmacological characterization of two novel, brain penetrating P2X₇ antagonists. ACS Med.Chem.Lett. 2013 PMID: 24900687
Bhattacharya Pharmacological characterization of a novel centrally permeable P2X₇ receptor antagonist: JNJ-47965567. Br.J.Pharmacol. 2013 PMID: 23889535