JNJ 28871063 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3352
Potent ErbB receptor family inhibitor
Key Product Details
Description
Potent ErbB receptor family inhibitor
Product Description
JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC50 = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.Product Specifications
Molecular Weight
519.42
Formula
C24H27ClN6O3.HCl
Storage
Desiccate at +4°C
Purity
≥97% (HPLC)
Chemical Name
5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride
CAS Number
944342-90-9
PubChem ID
17747413
InChI Key
ZXKZRKQMKNRZNN-GZPZNDDGSA-N
SMILES
NC1=C(/C=N/OCCN2CCOCC2)C(NC3=CC(Cl)=C(OCC4=CC=CC=C4)C=C3)=NC=N1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.97 | 50 |
Preparing Stock Solutions
for JNJ 28871063 hydrochloride
The following data is based on the product molecular weight 519.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.85 mL | 19.25 mL | 38.50 mL |
| 2.5 mM | 0.77 mL | 3.85 mL | 7.70 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.85 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Emanuel Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol. 2008 PMID: 17975007
- Guessous Signaling pathways in medulloblastoma. J.Cell.Phys. 2008 PMID: 18651559
- Contessa and Hamstra Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol. 2008 PMID: 17981994
Product Specific Notices for JNJ 28871063 hydrochloride
For research use only
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