JNJ 17203212

Tocris Bioscience, part of Bio-Techne | Catalog # 3361

Reversible, competitive and potent TRPV1 antagonist
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Key Product Details

Description

Reversible, competitive and potent TRPV1 antagonist

View all TRPV Antagonists »

Product Description

JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist (pKi values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H+-induced channel activation (pIC50 values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo.

Product Specifications

Molecular Weight

419.32

Formula

C17H15F6N5O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide

CAS Number

821768-06-3

PubChem ID

11339118

InChI Key

JFRYYGVYCWYIDQ-UHFFFAOYSA-N

SMILES

O=C(NC3=NC=C(C(F)(F)F)C=C3)N(CC2)CCN2C1=C(C(F)(F)F)C=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.93 100
Ethanol 41.93 100

Preparing Stock Solutions for JNJ 17203212

The following data is based on the product molecular weight 419.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.85 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Documents for JNJ 17203212

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JNJ 17203212

For research use only

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