JNJ 1013NC
Tocris Bioscience, part of Bio-Techne | Catalog # 8030
Negative control for the IRAK1 degrader JNJ 1013 (Cat. No. 8029)
Key Product Details
Description
Negative control for the IRAK1 degrader JNJ 1013 (Cat. No. 8029)
Product Description
JNJ 1013NC is the negative control for the IRAK1 degrader, JNJ 1013 (Cat. No. 8029).Product Specifications
Molecular Weight
878.06
Formula
C46H55N9O7S
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
N-(4-(4-(2-(((S)-1-((2S,4S)-4-Hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)piperidin-1-yl)-2-methoxyphenyl)-6-(1H-pyrazol-5-yl)picolinamide
CAS Number
2755075-91-1
PubChem ID
166627504
InChI Key
MHRNVFQJUUXQIG-LZJKKMSRSA-N
SMILES
O=C(C1=CC=CC(C2=NNC=C2)=N1)NC(C=C3)=C(OC)C=C3N(CC4)CCC4OCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 87.81 | 100 |
Preparing Stock Solutions
for JNJ 1013NC
The following data is based on the product molecular weight 878.06
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.14 mL | 5.69 mL | 11.39 mL |
| 5 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 10 mM | 0.11 mL | 0.57 mL | 1.14 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.23 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fu Discovery of highly potent and selective IRAK1 Degraders to probe scaffolding functions of IRAK1 in ABC DLBCL. J.Med.Chem. 2021 PMID: 34279092
Product Specific Notices for JNJ 1013NC
For research use only
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