JNJ 0966

Name: JNJ 0966
Brand: Tocris Bioscience
SKU: 6439

Tocris Bioscience a Bio-Techne Brand

Catalog # 6439

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Key Product Details

Description:	Pro-MMP9 activation inhibitor
Chemical Name:	N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	360.45

View Full Technical Details for JNJ 0966

Biological Activity for JNJ 0966

JNJ 0966 is a pro-MMP9 activation inhibitor (IC₅₀ = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.

Compound Libraries for JNJ 0966

JNJ 0966 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 0966

M. Wt	360.45
Formula	C₁₆H₁₆N₄O₂S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	315705-75-0
PubChem ID	1117189
InChi Key	ZADCDCMLLGDCRM-UHFFFAOYSA-N
Smiles	COC1=C(C=CC=C1)NC2=NC(C3=C(N=C(S3)NC(C)=O)C)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 0966

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.02	50

Preparing Stock Solutions for JNJ 0966

The following data is based on the product molecular weight 360.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.55 mL	27.74 mL	55.49 mL
2.5 mM	1.11 mL	5.55 mL	11.10 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
25 mM	0.11 mL	0.55 mL	1.11 mL

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References for JNJ 0966

References are publications that support the biological activity of the product.

Scannevin Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J.Biol.Chem. 2017 PMID: 28860188

Citations for JNJ 0966

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