JF-NP-26

Name: JF-NP-26
Brand: Tocris Bioscience
SKU: 6553

Catalog # 6553 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Caged Raseglurant (Cat. No. 4416)

Key Product Details

Description:	Caged Raseglurant (Cat. No. 4416)
Chemical Name:	(7-(Diethylamino)-2-oxo-2H-chromen-4-yl)methyl (2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyridin-3-yl)carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	513.56

View Full Technical Details for JF-NP-26

Technical Data
Citations / Reviews

Biological Activity for JF-NP-26

JF-NP-26 is a caged Raseglurant (Cat. No. 4416). Releases raseglurant upon exposure to 405 nm (violet) light. Inhibits the effects of Quisqualate (Cat. No. 0188) in cultured neurons when exposed to 405 nm light. Exhibits analgesic activity in pain models in vivo on photoactivation. Quantum yield = 0.18.

Technical Data for JF-NP-26

M. Wt	513.56
Formula	C₃₀H₂₈FN₃O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2341841-03-8
Smiles	CC1=CC(C)=C(NC(OCC2=CC(OC3=C2C=CC(N(CC)CC)=C3)=O)=O)C(C#CC4=CC=CC(F)=C4)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JF-NP-26

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	51.36	100

Preparing Stock Solutions for JF-NP-26

The following data is based on the product molecular weight 513.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.74 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for JF-NP-26

References are publications that support the biological activity of the product.

Font Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. eLIFE 2017 PMID: 28395733

Citations for JF-NP-26

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