JBJ-03-142-02
Tocris Bioscience, part of Bio-Techne | Catalog # 6962
Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors
Key Product Details
Description
Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors
Product Description
JBJ-03-142-02 is a highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor. Inhibits wild type and tumorgenic mutated receptors (exon 20 insertion; Ex20Ins). Antiproliferative in vitro (IC50 values are 7.6, 30 - 95, 3.8 and 19 - 31 nM for Ba/F3 cells expressing wild type EGFR, EGFR with Ex20Ins mutation, wild type HER2 and HER2 with Ex20Ins mutation, respectively). Also inhibits other common EGFR mutants. Antiproliferative in patient-derived lung cancer cell lines.Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
487.50
Formula
C25H22FN7O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(4-Fluorophenyl)methyl N-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate
CAS Number
2068806-31-3
PubChem ID
126496758
InChI Key
IFRXGTCPIGRGHP-UHFFFAOYSA-N
SMILES
CN1C=C(NC2=NC=CC(=N2)N(C(=O)OCC2=CC=C(F)C=C2)C2=CC(NC(=O)C=C)=CC=C2)C=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.37 | 50 |
Preparing Stock Solutions
for JBJ-03-142-02
The following data is based on the product molecular weight 487.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.10 mL | 20.51 mL | 41.03 mL |
| 2.5 mM | 0.82 mL | 4.10 mL | 8.21 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.10 mL |
| 25 mM | 0.08 mL | 0.41 mL | 0.82 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jang Discovery of a highly potent and broadly effective epidermal growth factor receptor and HER2 exon 20 insertion mutant inhibitor. Angew.Chem.Int.Ed.Engl. 2018 PMID: 29978938
Product Specific Notices for JBJ-03-142-02
For research use only
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