Ivosidenib
Tocris Bioscience, part of Bio-Techne | Catalog # 7761
Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)
Key Product Details
Description
Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)
Product Description
Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 μM. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro.Product Specifications
Molecular Weight
582.96
Formula
C28H22ClF3N6O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
CAS Number
1448347-49-6
PubChem ID
71657455
InChI Key
WIJZXSAJMHAVGX-DHLKQENFSA-N
SMILES
N([C@H](C(NC1CC(F)(F)C1)=O)C2=C(Cl)C=CC=C2)(C(=O)[C@H]3N(C(=O)CC3)C4=CC(C#N)=CC=N4)C=5C=C(F)C=NC5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.3 | 100 | |
| Ethanol | 58.3 | 100 |
Preparing Stock Solutions
for Ivosidenib
The following data is based on the product molecular weight 582.96
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.72 mL | 8.58 mL | 17.15 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.43 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.72 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zarei Wild-type IDH1 inhibition enhances chemotherapy response in melanoma. J.Exp.Clin.Cancer Res. 2022 PMID: 36153582
- Popovici-Muller Discovery of AG-120 (ivosidenib): a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers. ACS Med.Chem.Lett. 2018 PMID: 29670690
Product Specific Notices for Ivosidenib
For research use only
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