Ivabradine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6542

HCN channel blocker; inhibits If pacemaker current
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Key Product Details

Description

HCN channel blocker; inhibits If pacemaker current

View all HCN Channel Blockers »

Product Description

Ivabradine hydrochloride is a HCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells.

Product Specifications

Molecular Weight

505.05

Formula

C27H36N2O5.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

CAS Number

148849-67-6

PubChem ID

3045381

InChI Key

HLUKNZUABFFNQS-ZMBIFBSDSA-N

SMILES

COC1=C(C=C2[C@H](CC2=C1)CN(CCCN3CCC4=CC(OC)=C(C=C4CC3=O)OC)C)OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50.51 100
DMSO 50.51 100

Preparing Stock Solutions for Ivabradine hydrochloride

The following data is based on the product molecular weight 505.05

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.90 mL 19.80 mL
5 mM 0.40 mL 1.98 mL 3.96 mL
10 mM 0.20 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ivabradine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ivabradine hydrochloride

For research use only

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