Isoguvacine hydrochloride

Name: Isoguvacine hydrochloride
Brand: Tocris Bioscience
SKU: 0235

Catalog # 0235

Citations (5)

COA / SDS

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Key Product Details

Description:	Selective GABA_A agonist
Chemical Name:	1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	163.6

View Full Technical Details for Isoguvacine hydrochloride

Biological Activity

Isoguvacine hydrochloride is a specific GABA_A receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.

Technical Data

M. Wt	163.6
Formula	C₆H₉NO₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	68547-97-7
PubChem ID	155107
InChi Key	SUWREQRNTXCCBL-UHFFFAOYSA-N
Smiles	Cl.OC(=O)C=1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 163.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.11 mL	30.56 mL	61.12 mL
5 mM	1.22 mL	6.11 mL	12.22 mL
10 mM	0.61 mL	3.06 mL	6.11 mL
50 mM	0.12 mL	0.61 mL	1.22 mL

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References

References are publications that support the biological activity of the product.

Wahab Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 2009 PMID: 19535226
Krogsgaard-Larsen Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J.Neurochem. 1979 PMID: 448364
Krogsgaard-Larsen Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 1978 PMID: 670980

Citations for Isoguvacine hydrochloride (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Isoguvacine hydrochloride include:

Edwards et al. (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta. 1808:260
PMID: 20691150
Lobb et al. (2010) A dynamic role for GABA receptors on the firing pattern of midbrain DArgic neurons. J Neurophysiol. 104:403
PMID: 20445035
Long et al. (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. Br J Pharmacol. 284:8726
PMID: 19141616
Sipilä et al. (2009) Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci. 29:6982
PMID: 19474325
Wood et al. (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurosci. 131:1050
PMID: 11082110

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