Isoguvacine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0235
Selective GABAA agonist
Product Description
Isoguvacine hydrochloride is a specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.Product Specifications
Molecular Weight
163.60
Formula
C6H9NO2.HCl
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
CAS Number
68547-97-7
PubChem ID
155107
InChI Key
SUWREQRNTXCCBL-UHFFFAOYSA-N
SMILES
Cl.OC(=O)C=1CCNCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
for Isoguvacine hydrochloride
The following data is based on the product molecular weight 163.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.11 mL | 30.56 mL | 61.12 mL |
| 5 mM | 1.22 mL | 6.11 mL | 12.22 mL |
| 10 mM | 0.61 mL | 3.06 mL | 6.11 mL |
| 50 mM | 0.12 mL | 0.61 mL | 1.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Krogsgaard-Larsen Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J.Neurochem. 1979 PMID: 448364
- Wahab Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 2009 PMID: 19535226
- Krogsgaard-Larsen Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 1978 PMID: 670980
Product Specific Notices for Isoguvacine hydrochloride
For research use only
Loading...
Loading...