iso-PPADS tetrasodium salt

Name: iso -PPADS tetrasodium salt
Brand: tocris
SKU: 0683
Rating: 5 (1 reviews)

Catalog # 0683

Citations (5)

(1)

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Key Product Details

Description:	Non-selective P2X antagonist
Chemical Name:	Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Molecular Weight:	599.3

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Biological Activity

P2X-purinoceptor antagonist (pK_i = 6.5) with similar activity to PPADS.

2'4'-isomer also available.

Technical Data

M. Wt	599.3
Formula	C₁₄H₁₀N₃Na₄O₁₂PS₂
Storage	Desiccate at -20°C
CAS Number	207572-67-6
PubChem ID	5132514
InChi Key	LOTSPVPQHAUHCE-UHFFFAOYSA-N
Smiles	[Na+].[Na+].CC1=C(O)C(C=O)=C(CCP([O-])([O-])=O)C(\N=N\C2=C(C=CC(=C2)S(O)(=O)=O)S(O)(=O)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	59.93	100

Preparing Stock Solutions

The following data is based on the product molecular weight 599.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.67 mL	8.34 mL	16.69 mL
5 mM	0.33 mL	1.67 mL	3.34 mL
10 mM	0.17 mL	0.83 mL	1.67 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

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References

References are publications that support the biological activity of the product.

Connolly Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 1995 PMID: 7735699
Khakh Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 1994 PMID: 7843268
Trezise The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 1994 PMID: 8032652

Citations (5)

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Citations are publications that use Bio-Techne products. Selected citations for iso-PPADS tetrasodium salt include:

Uderhardt et al. (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 177:541
PMID: 30955887
Barría et al. (2018) Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Am J Trop Med Hyg. 98:105
PMID: 29141748
Palygin et al. (2018) Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal. 14:485
PMID: 30417216
Schneider et al. (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Am J Physiol Renal Physiol. 14:201
PMID: 26597723
Accorsi-Mendonça et al. (2013) Glial cells modulate the synaptic transmission of NTS neurons sending projections to ventral medulla of Wistar rats. Physiol Rep. 1:e00080
PMID: 24303152

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Good inhibitor

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

Cell Line/Tissue: phagocyte

H20 dilution 100 μM

PMID: PMID: 30955887

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Product Datasheets

COA

Certificate of Analysis

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iso-PPADS tetrasodium salt

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Key Product Details

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Biological Activity

Technical Data

Solubility

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References

Citations (5)

Customer Reviews (1)

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Good inhibitor

Product Datasheets

COA

Certificate of Analysis

SDS

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