iso-PPADS tetrasodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 0683
Non-selective P2X antagonist
Product Description
iso-PPADS tetrasodium salt is a P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS.2'4'-isomer also available.
Product Specifications
Molecular Weight
599.30
Formula
C14H10N3Na4O12PS2
Storage
Desiccate at -20°C
Chemical Name
Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
CAS Number
207572-67-6
PubChem ID
5132514
InChI Key
LOTSPVPQHAUHCE-UHFFFAOYSA-N
SMILES
[Na+].[Na+].CC1=C(O)C(C=O)=C(CCP([O-])([O-])=O)C(\N=N\C2=C(C=CC(=C2)S(O)(=O)=O)S(O)(=O)=O)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 59.93 | 100 |
Preparing Stock Solutions
for iso-PPADS tetrasodium salt
The following data is based on the product molecular weight 599.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.67 mL | 8.34 mL | 16.69 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.67 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Khakh Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 1994 PMID: 7843268
- Trezise The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 1994 PMID: 8032652
- Connolly Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 1995 PMID: 7735699
Product Specific Notices for iso-PPADS tetrasodium salt
For research use only
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