IRAK1/4 Inhibitor I

Name: IRAK1/4 Inhibitor I
Brand: Tocris Bioscience
SKU: 5665
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 5665

(1)

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Key Product Details

Description:	IRAK4 and IRAK1 inhibitor
Chemical Name:	N-[1-[2-(4-Morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitrobenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	395.41

View Full Technical Details for IRAK1/4 Inhibitor I

Biological Activity for IRAK1/4 Inhibitor I

IRAK1/4 Inhibitor I is an IRAK4 and IRAK1 inhibitor (IC₅₀ values are 0.2 and 0.3 μM, respectively).

Compound Libraries for IRAK1/4 Inhibitor I

IRAK1/4 Inhibitor I is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for IRAK1/4 Inhibitor I

M. Wt	395.41
Formula	C₂₀H₂₁N₅O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	509093-47-4
PubChem ID	11983295
InChi Key	QTCFYQHZJIIHBS-UHFFFAOYSA-N
Smiles	O=C(NC1=NC(C=CC=C2)=C2N1CCN3CCOCC3)C4=CC=CC([N+]([O-])=O)=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IRAK1/4 Inhibitor I

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.91	20

Preparing Stock Solutions for IRAK1/4 Inhibitor I

The following data is based on the product molecular weight 395.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.65 mL	63.23 mL	126.45 mL
1 mM	2.53 mL	12.65 mL	25.29 mL
2 mM	1.26 mL	6.32 mL	12.65 mL
10 mM	0.25 mL	1.26 mL	2.53 mL

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Reconstitution Calculator

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References for IRAK1/4 Inhibitor I

References are publications that support the biological activity of the product.

Powers Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg.Med.Chem.Lett. 2006 PMID: 16563752

Citations for IRAK1/4 Inhibitor I

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Customer Reviews for IRAK1/4 Inhibitor I (1)

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Great for kinase assays and kinetics

Name: Scott Scarneo

Species: Human

Assay Type: In Vitro

Easy to use for kinase assay to compare IRAK4 SAR analogs.

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