IRAK1/4 Inhibitor I
Tocris Bioscience, part of Bio-Techne | Catalog # 5665
IRAK4 and IRAK1 inhibitor
Product Description
IRAK1/4 Inhibitor I is an IRAK4 and IRAK1 inhibitor (IC50 values are 0.2 and 0.3 μM, respectively).Product Specifications
Molecular Weight
395.41
Formula
C20H21N5O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[1-[2-(4-Morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitrobenzamide
CAS Number
509093-47-4
PubChem ID
11983295
InChI Key
QTCFYQHZJIIHBS-UHFFFAOYSA-N
SMILES
O=C(NC1=NC(C=CC=C2)=C2N1CCN3CCOCC3)C4=CC=CC([N+]([O-])=O)=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.91 | 20 |
Preparing Stock Solutions
for IRAK1/4 Inhibitor I
The following data is based on the product molecular weight 395.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.65 mL | 63.23 mL | 126.45 mL |
| 1 mM | 2.53 mL | 12.65 mL | 25.29 mL |
| 2 mM | 1.26 mL | 6.32 mL | 12.65 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Powers Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg.Med.Chem.Lett. 2006 PMID: 16563752
Product Specific Notices for IRAK1/4 Inhibitor I
For research use only
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