IQ 3
Tocris Bioscience, part of Bio-Techne | Catalog # 4550
Selective JNK3 inhibitor
Discontinued Product
4550 has been discontinued.
View all JNK/c-jun Inhibitors products.
Product Description
IQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.Product Specifications
Molecular Weight
341.32
Formula
C20H11N3O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime
CAS Number
312538-03-7
PubChem ID
777728
InChI Key
WBSWWONMTZEOGS-UHFFFAOYSA-N
SMILES
O=C(C5=CC=CO5)O/N=C3C2=NC1=CC=CC=C1N=C2C4=C/3C=CC=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.83 | 20 |
Preparing Stock Solutions
for IQ 3
The following data is based on the product molecular weight 341.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.65 mL | 73.25 mL | 146.49 mL |
| 1 mM | 2.93 mL | 14.65 mL | 29.30 mL |
| 2 mM | 1.46 mL | 7.32 mL | 14.65 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.93 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schepetkin Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 2012 PMID: 22434859
Product Specific Notices for IQ 3
For research use only
Loading...
Loading...