IQ 3

Name: IQ 3
Brand: Tocris Bioscience
SKU: 4550

Tocris Bioscience, part of Bio-Techne | Catalog # 4550

Citations (2)

COA / SDS

Selective JNK3 inhibitor

Discontinued Product

4550 has been discontinued. View all JNK/c-jun Inhibitors products.

Key Product Details

Description:	Selective JNK3 inhibitor
Chemical Name:	11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime
Purity:	≥98% (HPLC)
Molecular Weight:	341.32

View Full Technical Details for IQ 3

Technical Data
Citations

Biological Activity for IQ 3

IQ 3 is a selective JNK3 inhibitor (K_d values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells (IC₅₀ = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.

Technical Data for IQ 3

M. Wt	341.32
Formula	C₂₀H₁₁N₃O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	312538-03-7
PubChem ID	777728
InChi Key	WBSWWONMTZEOGS-UHFFFAOYSA-N
Smiles	O=C(C5=CC=CO5)O/N=C3C2=NC1=CC=CC=C1N=C2C4=C/3C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for IQ 3

References are publications that support the biological activity of the product.

Schepetkin Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 2012 PMID: 22434859

IQ 3

Tocris Bioscience, part of Bio-Techne | Catalog # 4550

Key Product Details

Biological Activity for IQ 3

Technical Data for IQ 3

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for IQ 3

Product Documents for IQ 3

COA

Certificate of Analysis

SDS

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