Ipsapirone

Name: Ipsapirone
Brand: Tocris Bioscience
SKU: 1869

Tocris Bioscience, part of Bio-Techne | Catalog # 1869

Citations (12)

COA / SDS

Selective 5-HT1A agonist

Key Product Details

Description:	Selective 5-HT_1A agonist
Alternative Names:	TVX Q 7821
Chemical Name:	2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide
Purity:	≥99% (HPLC)
Molecular Weight:	401.48

View Full Technical Details for Ipsapirone

Technical Data
Citations

Biological Activity for Ipsapirone

Ipsapirone is a selective 5-HT_1A receptor agonist (K_i = 10 nM). Anxiolytic in vivo.

Technical Data for Ipsapirone

M. Wt	401.48
Formula	C₁₉H₂₃N₅O₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	95847-70-4
PubChem ID	56971
InChi Key	TZJUVVIWVWFLCD-UHFFFAOYSA-N
Smiles	O=C1N(CCCCN2CCN(CC2)C2=NC=CC=N2)S(=O)(=O)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ipsapirone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.01	10

Preparing Stock Solutions for Ipsapirone

The following data is based on the product molecular weight 401.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.91 mL	124.54 mL	249.08 mL
0.5 mM	4.98 mL	24.91 mL	49.82 mL
1 mM	2.49 mL	12.45 mL	24.91 mL
5 mM	0.50 mL	2.49 mL	4.98 mL

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Reconstitution Calculator

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References for Ipsapirone

References are publications that support the biological activity of the product.

Glaser and Traber Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites. Naunyn-Schmied.Arch.Pharmacol.
Traber Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821. Brain Res.Bull. 1984 PMID: 6541079
Maj Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and DArgic functions. J.Neural.Transm. 1987 PMID: 2889795