IOX 2

Name: IOX 2
Brand: Tocris Bioscience
SKU: 4451
Price: 258 USD

Catalog # 4451 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor

Key Product Details

Description:	Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
Chemical Name:	N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Purity:	≥99% (HPLC)
Molecular Weight:	352.34

View Full Technical Details for IOX 2

Biological Activity for IOX 2

IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC₅₀ = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 2 probe summary on the SGC website.

Compound Libraries for IOX 2

IOX 2 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for IOX 2

M. Wt	352.34
Formula	C₁₉H₁₆N₂O₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	931398-72-0
PubChem ID	54685215
InChi Key	CAOSCCRYLYQBES-UHFFFAOYSA-N
Smiles	OC(C1=CC=CC=C1N2CC3=CC=CC=C3)=C(C(NCC(O)=O)=O)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IOX 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.23	100

Preparing Stock Solutions for IOX 2

The following data is based on the product molecular weight 352.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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Reconstitution Calculator

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References for IOX 2

References are publications that support the biological activity of the product.

Murray Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J.Comb.Chem. 2010 PMID: 20666436

Citations for IOX 2 (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for IOX 2 include:

Christopher J et al. (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res. 82:3375-3393
PMID: 35819261
Navdeep S et al. (2021) Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway. Cell Rep. 36:109547
PMID: 34407414

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