Iodophenpropit dihydrobromide

Name: Iodophenpropit dihydrobromide
Brand: Tocris Bioscience
SKU: 0779

Catalog # 0779

Citations (2)

COA / SDS

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Key Product Details

Description:	Potent, selective H₃ antagonist
Chemical Name:	N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	576.13

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Biological Activity

Iodophenpropit dihydrobromide is a selective H₃ antagonist with high affinity (K_D = 0.3 nM).

Licensing Information

Sold with the permission of SCI, Amsterdam

Technical Data

M. Wt	576.13
Formula	C₁₅H₁₉IN₄S.2HBr
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	145196-87-8
PubChem ID	24978528
InChi Key	BOSOGNBLIWPCMS-UHFFFAOYSA-N
Smiles	Br.Br.IC1=CC=C(CCNC(=N)SCCCC2=CNC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	14.4	25

Preparing Stock Solutions

The following data is based on the product molecular weight 576.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	6.94 mL	34.71 mL	69.43 mL
1.25 mM	1.39 mL	6.94 mL	13.89 mL
2.5 mM	0.69 mL	3.47 mL	6.94 mL
12.5 mM	0.14 mL	0.69 mL	1.39 mL

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References

References are publications that support the biological activity of the product.

Shahid Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J.
Jansen Characterisation of the binding of the first selective radiolabelled histamine H₃ receptor antagonist, [¹²⁵I]-iodophenpropit, to rat brain. Br.J.Pharmacol. 1994 PMID: 7834183
Jansen The first radiolabelled histamine H₃ receptor antagonist, [¹²⁵I]iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur.J.Pharmacol. 1992 PMID: 1330590
Menge Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[¹²⁵I]-iodophenylethyl]isothiourea sulfate [¹²⁵I]-iodophenpropit), a new probe for histamine H₃ receptor binding sites. J.Labelled Comp.Radiopharm. XXXI

Citations for Iodophenpropit dihydrobromide (2)

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Citations are publications that use Bio-Techne products. Selected citations for Iodophenpropit dihydrobromide include:

Otvos et al. (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. BMC Neurosci. 7:2336
PMID: 26114334
Spaethling et al. (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Toxins (Basel). 28:771
PMID: 24192459

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