INT 131

Name: INT 131
Brand: Tocris Bioscience
SKU: 7423

Tocris Bioscience, part of Bio-Techne | Catalog # 7423

COA / SDS

PPARγ partial agonist

Key Product Details

Description:	PPARγ partial agonist
Chemical Name:	2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	514.21

View Full Technical Details for INT 131

Technical Data
Citations

Biological Activity for INT 131

INT 131 is a potent and selective PPARγ partial agonist (EC₅₀ = 4 nM; K_i= 3.7 nM). It has a 20-fold higher affinity for PPARγ compared with that of Rosiglitazone (Cat. No. 5325). INT 131 improves glucose tolerance in a rodent model of diabetes without inducing hemodynamic and cardiovascular effects. Antidiabetic agent.

Technical Data for INT 131

M. Wt	514.21
Formula	C₂₁H₁₂Cl₄N₂O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	315224-26-1
PubChem ID	10229498
InChi Key	NMRWDFUZLLQSBN-UHFFFAOYSA-N
Smiles	O=S(=O)(NC1=CC(Cl)=C(OC2=CN=C3C=CC=CC3=C2)C(Cl)=C1)C4=CC=C(Cl)C=C4Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for INT 131

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	2.57	5
	ethanol	2.57	5

Preparing Stock Solutions for INT 131

The following data is based on the product molecular weight 514.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	38.89 mL	194.47 mL	388.95 mL
0.25 mM	7.78 mL	38.89 mL	77.79 mL
0.5 mM	3.89 mL	19.45 mL	38.89 mL
2.5 mM	0.78 mL	3.89 mL	7.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for INT 131

References are publications that support the biological activity of the product.

Motani INT131: a selective modulator of PPARγ. J.Mol.Biol. 2009 PMID: 19452630
Frkic Structure-activity relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) analogs for PPARγ-targeted antidiabetics. J.Med.Chem. 2017 PMID: 28485590