IND 1316
Tocris Bioscience, part of Bio-Techne | Catalog # 7685
AMPK activator
Product Description
IND 1316 is an activator of AMP-activated protein kinase (AMPK). In vitro, it activates AMPK in a dose-dependent manner and induces different MAPK pathways (p38 and JNK). In vivo, it reduces the neuropathological symptoms in two animal models of Huntington's Disease (nematodes and mice). It shows very low toxicity even at high concentrations (>200 μM). This compound is orally bioavailable.Product Specifications
Molecular Weight
343.38
Formula
C22H17NO3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-[3-(Phenylmethoxy)phenyl]-1H-indole-2-carboxylic acid
CAS Number
1888473-12-8
PubChem ID
130234214
InChI Key
WFARYZNGGCHILS-UHFFFAOYSA-N
SMILES
OC(C1=C(C2=CC(OCC3=CC=CC=C3)=CC=C2)C4=CC=CC=C4N1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.34 | 100 | |
| Ethanol | 34.34 | 100 |
Preparing Stock Solutions
for IND 1316
The following data is based on the product molecular weight 343.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.91 mL | 14.56 mL | 29.12 mL |
| 5 mM | 0.58 mL | 2.91 mL | 5.82 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.91 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Vela Neuroprotective effect of IND1316, an indole-based AMPK activator, in animal models of Huntington disease. ACS Chem.Neurosci. 2022 PMID: 34962383
Product Specific Notices for IND 1316
For research use only
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