INCB 024360-analog
Tocris Bioscience, part of Bio-Techne | Catalog # 6007
Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
Key Product Details
Description
Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
Product Description
INCB 024360-analog is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable.Product Specifications
Molecular Weight
271.64
Formula
C9H7ClFN5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
CAS Number
914471-09-3
PubChem ID
11978742
InChI Key
MUVQOOPKPBEAJZ-VQHVLOKHSA-N
SMILES
O/N=C(NC1=CC(Cl)=C(F)C=C1)/C2=NON=C2N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.16 | 100 | |
| Ethanol | 27.16 | 100 |
Preparing Stock Solutions
for INCB 024360-analog
The following data is based on the product molecular weight 271.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.68 mL | 18.41 mL | 36.81 mL |
| 5 mM | 0.74 mL | 3.68 mL | 7.36 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.68 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yue Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J.Med.Chem. 2009 PMID: 19507862
- Dounay Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway. J.Med.Chem. 2015 PMID: 26207924
- Weinmann Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 2016 PMID: 26836578
Product Specific Notices for INCB 024360-analog
For research use only
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