IMP 2373

Name: IMP 2373
Brand: Tocris Bioscience
SKU: 8171

Tocris Bioscience, part of Bio-Techne | Catalog # 8171

COA / SDS

pan-DUB activity-based probe with alkyne click handle

Key Product Details

Description:	pan-DUB activity-based probe with alkyne click handle
Chemical Name:	4-(1-Cyanopyrrolidine-3-carbonyl)-N-[(4-ethynylphenyl)methyl]-1-methylpyrrole-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	360.42

View Full Technical Details for IMP 2373

Technical Data
Citations

Biological Activity for IMP 2373

IMP 2373 is a pan-deubiquitinase (pan-DUB) activity-based probe with alkyne click handle. IMP 2373 interacts with more than 35 DUBs in diverse cell lines and across a range of non-toxic concentrations. IMP 2373 can be used to monitor changes in intracellular DUB activity in live cells during pharmacological inhibition and in vivo during MYC deregulation in a model of B cell lymphoma.

Technical Data for IMP 2373

M. Wt	360.42
Formula	C₂₁H₂₀N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	169494136
InChi Key	URHCOQKMCOCJCX-UHFFFAOYSA-N
Smiles	C#CC1=CC=C(CNC(C2=CC(C(C3CN(C#N)CC3)=O)=CN2C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IMP 2373

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.04	100
	ethanol	36.04	100

Preparing Stock Solutions for IMP 2373

The following data is based on the product molecular weight 360.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.75 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for IMP 2373

References are publications that support the biological activity of the product.

Conole Discovery of a potent Deubiquitinase (DUB) small-molecule activity-based probe enables broad spectrum DUB activity profiling in living cells. Angew Chem.Int.Ed.Engl. 2023 PMID: 37779326