Immepip dihydrobromide

Name: Immepip dihydrobromide
Brand: Tocris Bioscience
SKU: 0932
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0932

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Key Product Details

Description:	Standard H₃ agonist. Also H₄ agonist
Chemical Name:	4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
Molecular Weight:	327.06

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Biological Activity for Immepip dihydrobromide

Immepip dihydrobromide is a potent histamine H₃ receptor agonist. Also binds to H₄ receptors (K_i values are 0.4 and 9 nM at human recombinant H₃ and H₄ receptors respectively). Equipotent to or slightly more active than (R)-α-methylhistamine at H₃ receptors.

Technical Data for Immepip dihydrobromide

M. Wt	327.06
Formula	C₉H₁₅N₃.2HBr
Storage	Desiccate at RT
CAS Number	164391-47-3
PubChem ID	22315065
InChi Key	YGNJPNRDGXJQJX-UHFFFAOYSA-N
Smiles	Br.Br.C(C1CCNCC1)C1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Immepip dihydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	32.71	100

Preparing Stock Solutions for Immepip dihydrobromide

The following data is based on the product molecular weight 327.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.06 mL	15.29 mL	30.58 mL
5 mM	0.61 mL	3.06 mL	6.12 mL
10 mM	0.31 mL	1.53 mL	3.06 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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References for Immepip dihydrobromide

References are publications that support the biological activity of the product.

Liu Cloning and pharmacological characterization of a fourth histamine receptor (H₄) expressed in bone marrow. Mol. Pharmacol. 2001 PMID: 11179434
Coruzzi Cardiovascular effects of selective agonists and antagonists of histamine H₃ receptors in the anaesthetized rat. Naunyn Schmiedebergs Arch.Pharmacol. 1995 PMID: 7675114
Vollinga A new potent and selective histamine H₃ receptor agonist. J.Med.Chem. 1994 PMID: 8308858

Citations for Immepip dihydrobromide (1)

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Citations are publications that use Bio-Techne products. Selected citations for Immepip dihydrobromide include:

Gründemann et al. (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol. 137:910
PMID: 12411423

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Customer Reviews for Immepip dihydrobromide (1)

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Study of H4 receptor in the DGR neurons

Name: Anonymous

Species: Human

To test the potential role of H4 receptor in the DRG neurons, we first investigated the effects of H4 agonist immepip dihydrobromide (immepip) and histamine to in dissociated DRG neurons.

We applied 50 μM immepip and histamine to the dissociated DRG neurons in a chamber perfusion solution.

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Product Documents for Immepip dihydrobromide

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.