Imiquimod

Name: Imiquimod
Brand: Tocris Bioscience
SKU: 3700

Tocris Bioscience, part of Bio-Techne | Catalog # 3700

Citations (21)

COA / SDS

Toll-like receptor 7 (TLR7) agonist

Key Product Details

Description:	Toll-like receptor 7 (TLR7) agonist
Alternative Names:	R 837
Chemical Name:	1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	240.3

View Full Technical Details for Imiquimod

Technical Data
Citations

Biological Activity for Imiquimod

Imiquimod is an immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR7) agonist; stimulates proinflammatory cytokine production and activates NF-κB.

Technical Data for Imiquimod

M. Wt	240.3
Formula	C₁₄H₁₆N₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	99011-02-6
PubChem ID	57469
InChi Key	DOUYETYNHWVLEO-UHFFFAOYSA-N
Smiles	CC(C)CN2C=NC1=C(N)N=C3C(C=CC=C3)=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Imiquimod

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.2	5 with gentle warming

Preparing Stock Solutions for Imiquimod

The following data is based on the product molecular weight 240.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	83.23 mL	416.15 mL	832.29 mL
0.25 mM	16.65 mL	83.23 mL	166.46 mL
0.5 mM	8.32 mL	41.61 mL	83.23 mL
2.5 mM	1.66 mL	8.32 mL	16.65 mL

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Reconstitution Calculator

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References for Imiquimod

References are publications that support the biological activity of the product.

Averett The pharmacology of endosomal TLR agonists in viral disease. Biochem.Soc.Trans. 2007 PMID: 18031247
Syed A review of the applications of imiquimod: a novel immune response modifier. Exp.Opin.Pharmacother.
Schon and Schon The antitumoral mode of action of imiq. and other imidazoquinolines. Curr.Med.Chem. 2007 PMID: 17346155