Imiquimod
Tocris Bioscience, part of Bio-Techne | Catalog # 3700
Toll-like receptor 7 (TLR7) agonist
Key Product Details
Description
Toll-like receptor 7 (TLR7) agonist
Alternative Names
R 837
Product Description
Imiquimod is an immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR7) agonist; stimulates proinflammatory cytokine production and activates NF-κB.Product Specifications
Molecular Weight
240.30
Formula
C14H16N4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
CAS Number
99011-02-6
PubChem ID
57469
InChI Key
DOUYETYNHWVLEO-UHFFFAOYSA-N
SMILES
CC(C)CN2C=NC1=C(N)N=C3C(C=CC=C3)=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1.2 | 5 with gentle warming |
Preparing Stock Solutions
for Imiquimod
The following data is based on the product molecular weight 240.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 83.23 mL | 416.15 mL | 832.29 mL |
| 0.25 mM | 16.65 mL | 83.23 mL | 166.46 mL |
| 0.5 mM | 8.32 mL | 41.61 mL | 83.23 mL |
| 2.5 mM | 1.66 mL | 8.32 mL | 16.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Averett The pharmacology of endosomal TLR agonists in viral disease. Biochem.Soc.Trans. 2007 PMID: 18031247
- Syed A review of the applications of imiquimod: a novel immune response modifier. Exp.Opin.Pharmacother.
- Schon and Schon The antitumoral mode of action of imiq. and other imidazoquinolines. Curr.Med.Chem. 2007 PMID: 17346155
Product Specific Notices for Imiquimod
For research use only
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