Imiloxan hydrochloride

Name: Imiloxan hydrochloride
Brand: Tocris Bioscience
SKU: 0986

Tocris Bioscience a Bio-Techne Brand

Catalog # 0986

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Key Product Details

Description:	Highly selective α_2B antagonist
Alternative Names:	RS 21361
Chemical Name:	2-(1-Ethyl-2-indazoyl)methyl-1,4-benzodioxan hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	280.75

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Biological Activity for Imiloxan hydrochloride

Imiloxan hydrochloride is a moderately potent, but highly selective α₂-adrenoceptor antagonist, the only reported selective antagonist at the α_2B-adrenoceptor not having potent α₁-adrenoceptor antagonist activity.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for Imiloxan hydrochloride

M. Wt	280.75
Formula	C₁₄H₁₆N₂O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	81167-22-8
PubChem ID	172975
InChi Key	ANDJPJNFVJXEKX-UHFFFAOYSA-N
Smiles	Cl.CCN1C=CN=C1CC1COC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Imiloxan hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	28.07	100

Preparing Stock Solutions for Imiloxan hydrochloride

The following data is based on the product molecular weight 280.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.56 mL	17.81 mL	35.62 mL
5 mM	0.71 mL	3.56 mL	7.12 mL
10 mM	0.36 mL	1.78 mL	3.56 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

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References for Imiloxan hydrochloride

References are publications that support the biological activity of the product.

Michel Assessment of imiloxan as a selective α_2B-adrenoceptor antagonist. Br.J.Pharmacol. 1990 PMID: 1970500
Michel and Whiting 2-(2-Imidazolylmethyl)-1,4-benzodioxans, a series of selective alpha₂-adrenoceptor antagonists. Br.J.Pharmacol.

Citations for Imiloxan hydrochloride

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