Imetit dihydrobromide

Name: Imetit dihydrobromide
Brand: tocris
SKU: 0729

Catalog # 0729

Citations (3)

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Key Product Details

Description:	Standard H₃ and H₄ agonist (H₃ > H₄)
Chemical Name:	5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	332.06

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Biological Activity

Imetit dihydrobromide is an an extremely potent, high affinity agonist at H₃ and H₄ receptors (K_i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC₅₀ of 25 nM. Centrally active following systemic administration.

Technical Data

M. Wt	332.06
Formula	C₆H₁₀N₄S.2HBr
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	32385-58-3
PubChem ID	11957573
InChi Key	DOBOYMKCRRLTRF-UHFFFAOYSA-N
Smiles	Br.Br.NC(=N)SCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	33.21	100

Preparing Stock Solutions

The following data is based on the product molecular weight 332.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.06 mL	30.12 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References

References are publications that support the biological activity of the product.

Farzin and Attarzadeh Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 2000 PMID: 10980276
Garbarg S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H₃ receptor agonist. J.Pharmacol.Exp.Ther. 1992 PMID: 1383495
Ling Histamine H₄ receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br.J.Pharmacol. 2004 PMID: 15131002

Citations (3)

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Citations are publications that use Bio-Techne products. Selected citations for Imetit dihydrobromide include:

Hashikawa-Hobara et al. (2012) Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart. Evid Based Complement Alternat Med. 340:185
PMID: 22011436
Yoshimoto et al. (2006) Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proc Natl Acad Sci U S A. 103:13866
PMID: 16954192
Flamand et al. (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol. 141:552
PMID: 14744809

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Imetit dihydrobromide

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References

Citations (3)

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