Ifenprodil hemitartrate
Tocris Bioscience, part of Bio-Techne | Catalog # 0545
Non-competitive NMDA antagonist; also σ ligand
Key Product Details
Description
Non-competitive NMDA antagonist; also σ ligand
Product Description
Ifenprodil hemitartrate is a NMDA receptor antagonist, acting at the polyamine site. Also an α-adrenergic vasodilator. σ2 ligand displaying about 3-fold selectivity over σ1 sites.Product Specifications
Molecular Weight
400.49
Formula
C21H27NO2.½C4H6O6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
PubChem ID
3689
InChI Key
UYNVMODNBIQBMV-UHFFFAOYSA-N
SMILES
OC1=CC=C([C@H]([C@@H](N2CCC(CC3=CC=CC=C3)CC2)C)O)C=C1.OC4=CC=C([C@H]([C@@H](N5CCC(CC6=CC=CC=C6)CC5)C)O)C=C4.O=C([C@H]([C@@H](C(O)=O)O)O)O.OC7=CC=C([C@@H]([C@H](N8CCC(CC9=CC=CC=C9)CC8)C)O)C=C7.OC%10=CC=C([C@@H]([C@H](N%11CCC(CC%12=CC=CC=C%12)CC%11)C)O)C=C%10.O=C([C@@H]([C@H](C(O)=O)O)O)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4 | 10 | |
| DMSO | 40.05 | 100 |
Preparing Stock Solutions
for Ifenprodil hemitartrate
The following data is based on the product molecular weight 400.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.48 mL | 24.97 mL |
| 5 mM | 0.50 mL | 2.50 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shalaby Neuroprotective effects of the N-MthD.-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. J.Pharmacol.Exp.Ther. 1992 PMID: 1346650
- Schoemaker Polyamine-sensitive binding of [3H]ifenprodil, a novel NMDA antagonist to the rat cerebral cortex. Eur.J.Pharmacol. 1990 PMID: 2178949
- Reynolds and Miller Ifenprodil is a novel type of N-MthD.-aspartate receptor antagonist: interaction with polyamines. Mol.Pharmacol. 1989 PMID: 2555674
- Gotti Ifenprodil and SL-82,0715 as cerebral anti-ischemic agents. 1. Evidence for efficacy in models of focal cerebral ischemia. J.Pharmacol.Exp.Ther. 1988 PMID: 2849668
Product Specific Notices for Ifenprodil hemitartrate
For research use only
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