Idebenone
Tocris Bioscience, part of Bio-Techne | Catalog # 3002
Antioxidant and neuroprotective agent
Discontinued Product
3002 has been discontinued.
View all Additional Antioxidant Compounds products.
Key Product Details
Description
Antioxidant and neuroprotective agent
Product Description
Idebenone is an antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo. Inhibits apoptosis of astrocytes via increased NGF production.Product Specifications
Molecular Weight
338.44
Formula
C19H30O5
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
CAS Number
58186-27-9
PubChem ID
3686
InChI Key
JGPMMRGNQUBGND-UHFFFAOYSA-N
SMILES
O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.84 | 100 | |
| Ethanol | 33.84 | 100 |
Preparing Stock Solutions
for Idebenone
The following data is based on the product molecular weight 338.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.77 mL | 29.55 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.91 mL |
| 10 mM | 0.30 mL | 1.48 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Civenni Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. Eur.J.Pharmacol. 1999 PMID: 10323265
- Takuma CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production. Eur.J.Pharmacol. 2000 PMID: 11040339
- Zs-Nagy Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review. Arch.Gerontol.Geriatr. 1990 PMID: 15374467
Product Specific Notices for Idebenone
For research use only
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