ICI 63197

Name: ICI 63197
Brand: Tocris Bioscience
SKU: 1816

Tocris Bioscience, part of Bio-Techne | Catalog # 1816

COA / SDS

PDE4 inhibitor

Discontinued Product

1816 has been discontinued. View all Phosphodiesterase Inhibitors products.

Key Product Details

Description:	PDE4 inhibitor
Chemical Name:	2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
Purity:	≥99% (HPLC)
Molecular Weight:	207.23

View Full Technical Details for ICI 63197

Technical Data
Citations

Biological Activity for ICI 63197

Potent phosphodiesterase (PDE) 4 inhibitor (IC₅₀ = 35 nM for inhibition of [³H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo.

Technical Data for ICI 63197

M. Wt	207.23
Formula	C₉H₁₃N₅O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	27277-00-5
PubChem ID	62824
InChi Key	UQDVRVNMIJAGRK-UHFFFAOYSA-N
Smiles	CCCN1C2=NC(N)=NN2C=C(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ICI 63197

References are publications that support the biological activity of the product.

Wachtel Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology 1983 PMID: 6302550
Zhao Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [³H]piclamilast and [³H]rolipram J.Pharmacol.Exp.Ther. 2003 PMID: 12704225
Kaulen Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [³H]rolipram. Brain Res. 1989 PMID: 2557965

ICI 63197

Tocris Bioscience, part of Bio-Techne | Catalog # 1816

Key Product Details

Biological Activity for ICI 63197

Technical Data for ICI 63197

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ICI 63197

Product Documents for ICI 63197

COA

Certificate of Analysis

SDS

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