ICI 204,448 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0822
κ agonist, acts peripherally
Key Product Details
Description
κ agonist, acts peripherally
Product Description
ICI 204,448 hydrochloride is a peripherally acting κ agonist.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
501.84
Formula
C23H26Cl2N2O4.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride
CAS Number
121264-04-8
PubChem ID
129407
InChI Key
FNDGLVOYAQNQPE-UHFFFAOYSA-N
SMILES
Cl.CN(C(CN1CCCC1)C1=CC(OCC(O)=O)=CC=C1)C(=O)CC1=CC(Cl)=C(Cl)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions
for ICI 204,448 hydrochloride
The following data is based on the product molecular weight 501.84
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.96 mL | 19.93 mL |
| 5 mM | 0.40 mL | 1.99 mL | 3.99 mL |
| 10 mM | 0.20 mL | 1.00 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shaw ICI-204,448: a κ-opioid agonist with limited access to the CNS. Br.J.Pharmacol. 1989 PMID: 2568146
- Keïta Antinociceptive effect of a κ-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur.J.Pharmacol. 1995 PMID: 7493620
Product Specific Notices for ICI 204,448 hydrochloride
For research use only
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