ICI 204,448 hydrochloride

Name: ICI 204,448 hydrochloride
Brand: tocris
SKU: 0822
Rating: 5 (1 reviews)

Catalog # 0822

Citations (1)

(1)

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Key Product Details

Description:	κ agonist, acts peripherally
Chemical Name:	(RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride
Purity:	≥98% (HPLC)

View Full Technical Details for ICI 204,448 hydrochloride

Biological Activity

Peripherally acting κ agonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt	501.84
Formula	C₂₃H₂₆Cl₂N₂O₄.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	121264-04-8
PubChem ID	129407
InChi Key	FNDGLVOYAQNQPE-UHFFFAOYSA-N
Smiles	Cl.CN(C(CN1CCCC1)C1=CC(OCC(O)=O)=CC=C1)C(=O)CC1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions

The following data is based on the product molecular weight 501.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.96 mL	19.93 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References

References are publications that support the biological activity of the product.

Keïta Antinociceptive effect of a κ-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur.J.Pharmacol. 1995 PMID: 7493620
Shaw ICI-204,448: a κ-opioid agonist with limited access to the CNS. Br.J.Pharmacol. 1989 PMID: 2568146

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Citations (1)

Citations are publications that use Bio-techne products. Selected citations for ICI 204,448 hydrochloride include:

Butelman et al. (2010) The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl). 210:253
PMID: 20084367

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Mouse EFS model

Name: John Broad | 5th Jan 2018

Species: Mouse

Assay Type: In Vitro

Inhibited mouse GI EFS smooth muscle contractions

ICI 204,448 hydrochloride

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Key Product Details

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Biological Activity

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References

Citations (1)

Customer Reviews

Mouse EFS model

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