ICI 174,864

Name: ICI 174,864
Brand: Tocris Bioscience
SKU: 0820

Catalog # 0820

Citations (5)

COA / SDS

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Key Product Details

Description:	δ selective peptide antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	691.87

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Biological Activity

ICI 174,864 is a selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt	691.87
Formula	C₃₈H₅₃N₅O₇
Single Letter Sequence	YXXFL (Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	89352-67-0
PubChem ID	44149909
InChi Key	XUWLAGNFLUARAN-CHQNGUEUSA-N
Smiles	CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble to 69.19mg/ml in DMSO and to 1mg/ml in water

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References

References are publications that support the biological activity of the product.

Cohen Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 1996 PMID: 2875170
Cowan Studies in vivo with ICI-174,864 and [D-Pen²,D-Pen⁵]-enkephalin. Neuropeptides 1985 PMID: 2987731
Hirning Studies in vitro with ICI-174,864 [D-Pen²,D-Pen⁵]-enkephalin (DPDPE) and [D-Ala²,NMePhe⁴,Gly-ol]-enkephalin (DAGO). Neuropeptides 1985 PMID: 2987739
Cotton ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 1984 PMID: 6323195

Citations for ICI 174,864 (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for ICI 174,864 include:

Birdsong et al. (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife. 8
PMID: 31099753
Leroy et al. (2017) Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron. 95:1089
PMID: 28823730
Gallego et al. (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. J Neurophysiol. 18:737
PMID: 18803462
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem. 283:29086
PMID: 18703511
Neilan et al. (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol. 128:556
PMID: 10516632

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