ICI 174,864
Tocris Bioscience, part of Bio-Techne | Catalog # 0820
δ selective peptide antagonist
Key Product Details
Description
δ selective peptide antagonist
Product Description
ICI 174,864 is a selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
691.87
Formula
C38H53N5O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
89352-67-0
PubChem ID
44149909
InChI Key
XUWLAGNFLUARAN-CHQNGUEUSA-N
SMILES
CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water and to 69.19mg/ml in DMSO |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Hirning Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 1985 PMID: 2987739
- Cotton ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 1984 PMID: 6323195
- Cowan Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 1985 PMID: 2987731
- Cohen Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 1996 PMID: 2875170
Product Specific Notices for ICI 174,864
For research use only
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